Stapokibart (CM310) is a high-efficient, humanized antibody targeting the interleukin-4 receptor alpha subunit (IL-4Rα), and is the first domestically manufactured IL-4Rα antibody drug granted marketing approval by the NMPA. By targeting IL-4Rα, Stapokibart can block both interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling. IL-4 and IL-13 are two key cytokines trigger type II inflammation. Stapokibart has demonstrated a favorable safety profile and encouraging efficacy across multiple clinical trials and has been approved for marketing for the treatment of moderate to severe atopic dermatitis in adults, chronic rhinosinusitis with nasal polyposis, and Seasonal Allergic Rhinitis in September 2024, December 2024 and January 2025, respectively.