Industry-leading Drug

Discovery Platform

Research Field

Autoimmune Disease

The causes of autoimmune diseases are complex. Stimulated by specific antigens, the immune system will be repeatedly or excessively activated, resulting in increased cytokine secretion, mediated immune response attacking normal tissues, or callus formation through compensatory pathways, thus impairing normal physiological functions.

 

Relying on our own antibody discovery and drug evaluation platform, we have developed highly-effective blocking antibodies for different types of autoimmune diseases to effectively reduce effector cell- and cytokine-mediated inflammatory responses, and then to influence the disease progress and to improve the quality of life in patients.

Oncology

The treatment of malignant tumors has significantly developed  in recent years, especially the continuous breakthroughs in cancer immunotherapy. To further improve the clinical benefits for more patients and develop more effective treatment methods, we have cooperated with top domestic academic institutions and well-known companies in the industry to identify new targets, new mechanisms of action, and new combinations. At present, multiple molecules are in different stages of drug development.

Neurodegeneration

Neurodegenerative diseases are a group of conditions characterized by the gradual atrophy and loss of specific neurons in the nervous system, resulting in chronic progressive pathological changes and functional impairments in corresponding structures. The main diseases in this category include Alzheimer's disease and Parkinson's disease. The pathogenesis of neurodegenerative diseases is not yet clear, and there are few therapeutic drugs available that can only alleviate symptoms and cannot reverse or prevent the loss of neurons. 

 

By leveraging of our proprietary platforms for discovery and evaluation of antibody and nucleic acid drug, we are developing various drugs for different neurodegenerative diseases. Among them, our independently developed antibody drug for Alzheimer's disease features in long half-life, low immunogenicity, and good clearance activity, which is expected to provide safer and more effective medication for patients with Alzheimer's disease.

R&D Platform
Innovative Antibody Discovery Platform

Innovative antibody discovery platform is designed to discover and evaluate antibody drug candidates. By integrating hybridoma and phage display library technology and AI techniques such as the latest machine learning, this platform can achieve high-throughput antibody screening、activity evaluation、developability assessment and molecular engineering and optimization, and related functions. Based on this platform, we have developed diverse antibody drugs including monoclonal antibodies such as CM310、CM326、CM313、CM383;bispecific antibodies such as CM512(TSLPxIL13)、CM536(OX40LxIL13)and antibody-drug conjugates such as CMG901(Cldn18.2 ADC)、CM518D1(CDH17 ADC).

Biological Activity Evaluation Platform

Biological Activity Evaluation Platform can assess candidate antibody drugs in terms of binding affinity, in vitro cellular activity, and in vivo efficacy. In vitro cell activity experiments are based on the mechanism of action of the antibody drug and use appropriate cell models (e.g., cell viability, proliferation, differentiation, and apoptosis) to screen and evaluate antibody molecules. Additionally, we have established dozens of animal models on this platform, including tumor CDX, autoimmune, and metabolic models, which allow for pharmacodynamic and pharmacological evaluation of antibody drugs in vivo.

Novel T Cell Engager (nTCE) Redirection Platform

Novel T Cell Engager (nTCE) Redirection Platform enables us to develop bispecific antibodies that are potent and highly CD3 targeted. This platform is designed to achieve deep clearance of target cells while effectively reduce cytokine release. The bispecific antibody drugs developed on this platform are both highly stable and productive. Based on this platform, we have developed multiple bispecific antibodies, including candidates such as CM355(CD20Xcd3)、CM336(BCMAxCD3)、CM350(GPC3XCD3) which have entered clinical stage.

Novel Antibody Drug Conjugate Platform

This platform has the comprehensive capabilities to develop novel ADCs with diverse combinations of novel payloads with different mechanisms of action, new types of hydrophilic linkers, and various novel antibodies by multi-conjugation techniques, which generates ADCs with full independent intellectual property rights, strong in vivo stability, excellent efficacy, and good safety. In addition to the MMAE payload and its MC-vc-PAB linker used in CMG901(AZD0901), we have successfully developed several new types of payloads of new topoisomerase inhibitors and novel linkers.

High-throughput Screening Platform for High Yield Cell Strains

This platform is designed for identifying high yielding cell strains to achieve more cost-efficient drug development, and it can successfully identify stable cell strains for drug candidates such as monoclonal antibodies and bispecific/multi-specific antibodies within three months.

Innovative Antibody Discovery Platform

Biological Activity Evaluation Platform

Novel T Cell Engager (nTCE) Redirection Platform

Novel Antibody Drug Conjugate Platform

High-throughput Screening Platform for High Yield Cell Strains

International-standard Biopharmaceutical
Manufacturing Facility
In accordance with the cGMP standards of NMPA, FDA and EMA
75,333
M2
Site area
5-15
 
Commercial-scale production
70,000
L
Fermentation scale

Located in Tianfu International

Bio-town, Chengdu, covering an

area of 75,333 M2

Satisfy commercial-scale

production of 5-15

antibodies simultaneously

Over 70,000L of Fermentation scale